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Biophysics Seminar (Virtual)

Date
Mon, Dec 6, 2021 4:00 pm - 5:00 pm
Location
Online using Zoom Meeting

Description

Title: Super-resolution imaging of chromatin organization in health and disease

SpeakerMelike Lakadamyali, University of Pennsylvania

Hosted by: Arpita Upadhyaya

Abstract: Human DNA is 2 meters in length and must be packaged into the small space of a cell’s nucleus. New technologies, including super-resolution microscopy, are revealing how the genome is folded and packaged inside intact nuclei. I will present our work on using super-resolution microscopy to visualize and quantify chromatin nano-structure in single cells. I will further talk about how the chromatin nano-structure can be remodeled via chemo-mechanical cues. Finally, I will show that degenerative chemo-mechanical cues during disease can lead to aberrant chromatin nano-structure, potentially impacting cell phenotype. 

Zoom Link:
https://umd.zoom.us/j/97881020532?pwd=L1ArV203ZlBmU1daMUtwd3VzUlppUT09
Meeting ID: 978 8102 0532
Passcode: 504141

BIPH websitehttps://ipst.umd.edu/graduate-programs/biophysics/events