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Category: Department News
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Published: Tuesday, September 06 2022 00:01
In the world of startups, opportunity can come knocking in strange ways. Six years ago, Didier Depireux (Ph.D. â91, physics) was doing research at the University of Maryland when he was approached by Sam Owen, a young scientist who said heâd developed a device to treat motion sickness. Depireux was skeptical but decided to check it out.
âSince I get very severe motion sickness, I made a deal with him,â Depireux recalled. âI said, âIâll come over with my car and you can drive me around while I use the device. If I havenât thrown up after 20 minutes while Iâm in the back of the car reading, Iâll join the effort.ââ
The two made plans to meet in Washington, D.C., on a muggy July afternoon.
Didier Depireux
âSo, I go to Georgetown. The windows are down, itâs hot, itâs humid and Iâm thinking I will not make it past the first turn,â Depireux explained. âOwen is driving and Iâm in the back seat using his device and reading my cellphone. And for the first time in my lifeâand Iâm over 50 years oldâI was able to read in the back of a car and not get sick. I thought, âI need to join this, this is amazing.ââ
Thanks to that strange summer ride-along, Depireux joined Owen in launching a startup called Otolith Labs to address inner ear-related conditions and their often debilitating symptoms. Otolithâs noninvasive vestibular system masking technologyâdesigned for acute treatment of vestibular vertigoâreceived the FDAâs Breakthrough Device designation and clinical trials are ongoing, with support from investors including AOL founder Jack Davies and billionaire entrepreneur Mark Cuban.
All of this sets the stage for a major test that could lead to the startupâs ultimate goalâFDA approval as early as next year.
âIn July we told the FDA we want to do a large-scale pivotal trial with hundreds of participants,â Depireux explained. âIf all goes well, weâll have a meeting next summer where the FDA will approve us and then the device will become available.â
For Depireux, itâs the latest step on a bigger mission that has guided his career.
Didier DepireuxâItâs mostly relevance,â he explained. âI would like my life to make a difference, thatâs the one thing that keeps me going.â
From philosophy to physics
Depireux was raised in Belgium. A bright, thoughtful boy, he grew up with a strong interest in science and theory, thanks to his father, a physics professor, and his mother, a chemistry teacher.
âI was always very science-y,â Depireux recalled. âInitially, I wanted to become a philosopher and I read this 800-page bookâI think it was Kantâand at the end of it I was like, âI still donât know the answer, and Iâm not even sure I understand the question anymore.â Thatâs when I thought thatâs not a good fit for me.â
Depireux eventually gravitated toward physics. After receiving his B.S. in physics from the University of Liège in Belgium in 1986, he began his graduate work in physics at the University of Maryland, where he focused on string theory and met Distinguished University Professor of Physics Sylvester James Gates Jr., who quickly became a mentor and friend.
âJim had a huge impact on me. He was a fantastic person to work with and he had so much positive energy,â Depireux said. âI still remember late one night I was working on something, and I was stuck and I wrote to him, and he said, âIâll come over, letâs work this out.â So we had office hours at 10:30 p.m. just because I couldnât solve a problem.â
Depireux earned his Ph.D. in 1991 and went on to do postdoctoral work in Quebec, Canada, before returning to College Park in 1994. Inspired by his wife Pamela, who was getting her Ph.D. in neuropharmacology, Depireux took on the challenge of modeling the brain and studying how it processes sound. By 2001, he was also teaching a gross anatomy class at the University of Maryland School of Medicine.
âI think, to this day, I am the only string theorist who has taught gross anatomy,â he reflected.
From his research on the brain and hearing, Depireux shifted his focus to tinnitusâdisruptive ringing in the ears. He explored possible treatments and eventually teamed up with former UMD Bioengineering Professor Benjamin Shapiro who was already working on the drug delivery challenges Depireux was trying to solve.
âI wanted to get drug delivery to the ear but I didnât know how to do it,â Depireux said. âHe had this method with nanoparticles to deliver drugs and I had the target so we started working together.â
In 2013, the two launched Otomagnetics, a startup that has made major strides in developing noninvasive methods to treat inner ear diseases and more.
âWeâve gotten very nice results as far as drug delivery goes and Otomagnetics is still an ongoing concern,â Depireux explained, âBut raising money for drug delivery is the real challenge, because to get drug delivery to the ear is going to take hundreds of millions of dollars, and that hasnât happened yet.â
Going all-in on Otolith
Depireux balanced his time between Otomagnetics, his UMD research and teaching at the School of Medicine until 2016, when he experienced Owenâs experimental motion sickness device for the first time. Depireux saw so much potential with the device that he went all-in on Otolith.
âYou have to have pretty strong resilience to join a startupâI went for a year and a half without a salary or anything,â Depireux explained. âItâs not like we didnât have money, we just needed all of the money to develop the device, get the patents in, all of the things we had to do.â
Though Otolith started with a motion sickness device, its co-founders hoped to make an even bigger impact by developing a device for vertigo, debilitating dizziness often caused by problems in the inner ear.
And they had a plan.
âFor tinnitus or ringing in the ears, some patients get relief from a noise maskerâthey can still perceive their tinnitus, but the noise masker allows them to ignore the tinnitus,â Depireux explained. âSo Sam, my cofounder said, âWhy donât we come up with a noise masker for the vestibular system?ââ
Thatâs exactly what they did. Their novel device, worn like a headband, treats vertigo by applying localized mechanical stimulation to the vestibular system through calibrated vibrations.
Depireux says he never would have made it this far without physics.
âMy physics training really helped me,â he explained. âIn physics, you have this huge problem and you have to break it down. If itâs intractable, you make it tractable, break it into small, simple things we can understand and then we can solve it.â
Promising results and personal stories
Clinical trials of Otolithâs investigational headband have yielded promising results. In the first of a series of ongoing clinical studies, 87.5% of the 40 participants reported a reduction in their vertigo within five minutes of turning on the device. But for Depireux, itâs the personal stories that are most rewarding.
âSomehow my phone number was listed as an emergency contact on clinicaltrials.gov, which I thought would be for emergencies only,â he said. âIâd have patients calling me in tears, telling me, âWhen my grandkids visit, I can finally bend down and pick them up, and it used to be that just bending down would send me into such vertigo that I would have to go to bed for days.â Or âFor the first time in years, Iâve been able to walk around the block.â Thatâs what really motivates me.â
It's been Depireuxâs goal all alongâdoing relevant research that changes peopleâs lives.
âWe cannot help 100% of vertigo patients, no device does that,â he reflected. âBut if we can help even half of those patients, thatâs really my hope.â
Looking back on a career path thatâs been anything but predictable, Depireux appreciates every challenge and setback that got him to where he is today.
âSomething can feel like a failure when things go wrong, but then later you realize you really learned something from it,â he reflected. âIâm so grateful I was given the opportunity to come to the U.S. and study physics and do research in College Park, do this random walk in my career and finally end up doing something that I feel has given me great meaning in my life.â
Written by Leslie Miller